Axion inflation in the strong-backreaction regime: decay of the Anber-Sorbo solution

Axion inflation coupled to Abelian gauge fields via a Chern-Simons-like term of the form $\phi F\tilde{F}$ represents an attractive inflationary model with a rich phenomenology, including the production of magnetic fields, black holes, gravitational waves, and the matter-antimatter asymmetry. In this work, we focus on a particular regime of axion inflation, the so-called Anber-Sorbo (AS) solution, in which the energy loss in the gauge-field production provides the dominant source of friction for the inflaton motion. We revisit the AS solution and confirm that it is unstable. Contrary to earlier numerical works that attempted to reach the AS solution starting from a regime of weak backreaction, we perform, for the first time, a numerical evolution starting directly from the regime of strong backreaction. Our analysis shows that, at least as long as one neglects spatial inhomogeneities in the inflaton field, the AS solution has no basin of attraction, not even a very small one that might have been missed in previous numerical studies. Our analysis employs an arsenal of analytical and numerical techniques, some established and some newly introduced, including (1) linear perturbation theory along the lines of arXiv:2209.08131, (2) the gradient expansion formalism (GEF) developed in arXiv:2109.01651, (3) a new linearized version of the GEF, and (4) the standard mode-by-mode approach in momentum space in combination with input from the GEF. All these methods yield consistent results confirming the instability of the AS solution, which renders the dynamics of axion inflation in the strong-backreaction regime even more interesting than previously believed.Comment: 40 pages, 11 figure

MSSM-inflation revisited: Towards a coherent description of high-energy physics and cosmology

The aim of this paper is to highlight the challenges and potential gains surrounding a coherent description of physics from the high-energy scales of inflation down to the lower energy scales probed in particle-physics experiments. As an example, we revisit the way inflation can be realised within an effective Minimal Supersymmetric Standard Model (eMSSM), in which the $LLe$ and $udd$ flat directions are lifted by the combined effect of soft-supersymmetric-breaking masses already present in the MSSM, together with the addition of effective non-renormalizable operators. We clarify some features of the model and address the question of the one-loop Renormalization Group improvement of the inflationary potential, discussing its impact on the fine-tuning of the model. We also compare the parameter space that is compatible with current observations (in particular the amplitude, $A_{\scriptscriptstyle{\mathrm{S}}}$, and the spectral index, $n_{\scriptscriptstyle{\mathrm{S}}}$, of the primordial cosmological fluctuations) at tree level and at one loop, and discuss the role of reheating. Finally we perform combined fits of particle and cosmological observables (mainly $A_{\scriptscriptstyle{\mathrm{S}}}$, $n_{\scriptscriptstyle{\mathrm{S}}}$, the Higgs mass, and the cold-dark-matter energy density) with the one-loop inflationary potential applied to some examples of dark-matter annihilation channels (Higgs-funnel, Higgsinos and A-funnel), and discuss the status of the ensuing MSSM spectra with respect to the LHC searches.Comment: 38 pages, 7 figure

PTArcade

This is a lightweight manual for PTArcade, a wrapper of ENTERPRISE and ceffyl that allows for easy implementation of new-physics searches in PTA data. In this manual, we describe how to get PTArcade installed (either on your local machine or an HPC cluster). We discuss how to define a stochastic or deterministic signal and how PTArcade implements these signals in PTA-analysis pipelines. Finally, we show how to handle and analyze the PTArcade output using a series of utility functions that come together with PTArcade.Comment: 26 pages, 2 figures, 2 table

A systematic comparison of all mutations in hereditary sensory neuropathy type I (HSAN I) reveals that the G387A mutation is not disease associated

Hereditary sensory neuropathy type 1 (HSAN I) is an autosomal dominant inherited neurodegenerative disorder of the peripheral nervous system associated with mutations in the SPTLC1 subunit of the serine palmitoyltransferase (SPT). Four missense mutations (C133W, C133Y, V144D and G387A) in SPTLC1 were reported to cause HSAN I. SPT catalyses the condensation of Serine and Palmitoyl-CoA, which is the first and rate-limiting step in the de novo synthesis of ceramides. Earlier studies showed that C133W and C133Y mutants have a reduced activity, whereas the impact of the V144D and G387A mutations on the human enzyme was not tested yet. In this paper, we show that none of the HSAN I mutations interferes with SPT complex formation. We demonstrate that also V144D has a reduced SPT activity, however to a lower extent than C133W and C133Y. In contrast, the G387A mutation showed no influence on SPT activity. Furthermore, the growth phenotype of LY-B cells—a SPTLC1 deficient CHO cell line—could be reversed by expressing either the wild-type SPTLC1 or the G387A mutant, but not the C133W mutant. This indicates that the G387A mutation is most likely not directly associated with HSAN I. These findings were genetically confirmed by the identification of a nuclear HSAN family which showed segregation of the G387A variant as a non-synonymous SN

The NANOGrav 15-year Data Set: Evidence for a Gravitational-Wave Background

We report multiple lines of evidence for a stochastic signal that is correlated among 67 pulsars from the 15-year pulsar-timing data set collected by the North American Nanohertz Observatory for Gravitational Waves. The correlations follow the Hellings-Downs pattern expected for a stochastic gravitational-wave background. The presence of such a gravitational-wave background with a power-law-spectrum is favored over a model with only independent pulsar noises with a Bayes factor in excess of $10^{14}$, and this same model is favored over an uncorrelated common power-law-spectrum model with Bayes factors of 200-1000, depending on spectral modeling choices. We have built a statistical background distribution for these latter Bayes factors using a method that removes inter-pulsar correlations from our data set, finding $p = 10^{-3}$ (approx. $3\sigma$) for the observed Bayes factors in the null no-correlation scenario. A frequentist test statistic built directly as a weighted sum of inter-pulsar correlations yields $p = 5 \times 10^{-5} - 1.9 \times 10^{-4}$ (approx. $3.5 - 4\sigma$). Assuming a fiducial $f^{-2/3}$ characteristic-strain spectrum, as appropriate for an ensemble of binary supermassive black-hole inspirals, the strain amplitude is $2.4^{+0.7}_{-0.6} \times 10^{-15}$ (median + 90% credible interval) at a reference frequency of 1/(1 yr). The inferred gravitational-wave background amplitude and spectrum are consistent with astrophysical expectations for a signal from a population of supermassive black-hole binaries, although more exotic cosmological and astrophysical sources cannot be excluded. The observation of Hellings-Downs correlations points to the gravitational-wave origin of this signal.Comment: 30 pages, 18 figures. Published in Astrophysical Journal Letters as part of Focus on NANOGrav's 15-year Data Set and the Gravitational Wave Background. For questions or comments, please email [email protected]

Axion inflation in the strong-backreaction regime: decay of the Anber-Sorbo solution

Abstract Axion inflation coupled to Abelian gauge fields via a Chern-Simons-like term of the form ϕF F ~ $$\phi F\overset{\sim }{F}$$ represents an attractive inflationary model with a rich phenomenology, including the production of magnetic fields, black holes, gravitational waves, and the matter-antimatter asymmetry. In this work, we focus on a particular regime of axion inflation, the so-called Anber-Sorbo (AS) solution, in which the energy loss in the gauge-field production provides the dominant source of friction for the inflaton motion. We revisit the AS solution and confirm that it is unstable. Contrary to earlier numerical works that attempted to reach the AS solution starting from a regime of weak backreaction, we perform, for the first time, a numerical evolution starting directly from the regime of strong backreaction. Our analysis strongly suggests that, at least as long as one neglects spatial inhomogeneities in the inflaton field, the AS solution has no basin of attraction, not even a very small one that might have been missed in previous numerical studies. Our analysis employs an arsenal of analytical and numerical techniques, some established and some newly introduced, including (1) linear perturbation theory along the lines of ref. [1], (2) the gradient expansion formalism (GEF) developed in ref. [2], (3) a new linearized version of the GEF, and (4) the standard mode-by-mode approach in momentum space in combination with input from the GEF. All these methods yield consistent results confirming the instability of the AS solution, which renders the dynamics of axion inflation in the strong-backreaction regime even more interesting than previously believed

MSSM-inflation revisited: Towards a coherent description of high-energy physics and cosmology

International audienceThe aim of this paper is to highlight the challenges and potential gains surrounding a coherent description of physics from the high-energy scales of inflation down to the lower energy scales probed in particle-physics experiments. As an example, we revisit the way inflation can be realised within an effective Minimal Supersymmetric Standard Model (eMSSM), in which the $LLe$ and $udd$ flat directions are lifted by the combined effect of soft-supersymmetric-breaking masses already present in the MSSM, together with the addition of effective non-renormalizable operators. We clarify some features of the model and address the question of the one-loop Renormalization Group improvement of the inflationary potential, discussing its impact on the fine-tuning of the model. We also compare the parameter space that is compatible with current observations (in particular the amplitude, $A_{\scriptscriptstyle{\mathrm{S}}}$, and the spectral index, $n_{\scriptscriptstyle{\mathrm{S}}}$, of the primordial cosmological fluctuations) at tree level and at one loop, and discuss the role of reheating. Finally we perform combined fits of particle and cosmological observables (mainly $A_{\scriptscriptstyle{\mathrm{S}}}$, $n_{\scriptscriptstyle{\mathrm{S}}}$, the Higgs mass, and the cold-dark-matter energy density) with the one-loop inflationary potential applied to some examples of dark-matter annihilation channels (Higgs-funnel, Higgsinos and A-funnel), and discuss the status of the ensuing MSSM spectra with respect to the LHC searches

PTArcade

This is a lightweight manual for PTArcade, a wrapper of ENTERPRISE and ceffyl that allows for easy implementation of new-physics searches in PTA data. In this manual, we describe how to get PTArcade installed (either on your local machine or an HPC cluster). We discuss how to define a stochastic or deterministic signal and how PTArcade implements these signals in PTA-analysis pipelines. Finally, we show how to handle and analyze the PTArcade output using a series of utility functions that come together with PTArcade

Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells

A low high-density lipoprotein (HDL) plasma concentration and the abundance of small dense low-density lipoproteins (LDL) are risk factors for developing type 2 diabetes. We therefore investigated whether HDL and LDL play a role in the regulation of pancreatic islet cell apoptosis, proliferation and secretory function. Isolated mouse and human islets were exposed to plasma lipoproteins of healthy human donors. In murine and human beta-cells LDL decreased both proliferation and maximal glucose-stimulated insulin secretion. The comparative analysis of beta-cells from wild type and LDL receptor deficient mice revealed that the inhibitory effect of LDL on insulin secretion but not on proliferation requires the LDL receptor. HDL was found to modulate the survival of both human and murine islets by decreasing basal as well as IL-1beta and glucose induced apoptosis. IL-1beta induced beta-cell apoptosis was also inhibited in the presence of either the delipidated protein or the deproteinated lipid moieties of HDL, apolipoprotein A1 (the main protein component of HDL) or sphingosine-1-phosphate (a bioactive sphingolipid mostly carried by HDL). In murine beta-cells, the protective effect of HDL against IL-1beta induced apoptosis was also observed in the absence of the HDL receptor scavenger receptor class B type 1 (SRB1). Our data show that both LDL and HDL affect function or survival of beta-cells and raise the question whether dyslipidemia contributes to beta-cell failure and hence the manifestation and progression of type 2 diabetes mellitus